2

Extensive patient-to-patient single nuclei transcriptome heterogeneity in pheochromocytomas and paragangliomas
Pheochromocytomas (PC) and paragangliomas (PG) are rare neuroendocrine tumors of varied genetic makeup, associated with high …
Peter Brazda, Cristian Ruiz-Moreno, Wout Megchelenbrink, Henri J L M Timmers, Hendrik G Stunnenberg
PDF Cite
Extensive patient-to-patient single nuclei transcriptome heterogeneity in pheochromocytomas and paragangliomas
Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia
The heterogeneity and evolution of AML blasts can render therapeutic interventions ineffective in a yet poorly understood …
Yanan Zhai, Prashant Singh, Anna Dolnik, Peter Brazda, Nader Atlasy, Nunzio del Gaudio, Konstanze Döhner, Hartmut Döhner, Saverio Minucci, Joost Martens, Lucia Altucci, Wout Megchelenbrink, Lars Bullinger, Hendrik G. Stunnenberg
PDF Cite
Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia
Behavioral-transcriptomic landscape of engineered T cells targeting human cancer organoids
Cellular immunotherapies are rapidly gaining clinical importance, yet predictive platforms for modeling their mode of action are …
Johanna F Dekkers, Maria Alieva, Astrid Cleven, Farid Keramati, Peter Brazda, Heggert G Rebel, Amber KL Wezenaar, Jens Puschhof, Maj-Britt Buchholz, Mario Barrera Román, Inez Johanna, Angelo D. Meringa, Domenico Fasci, Maarten H. Geurts, Hendrikus C.R. Ariese, Esmée J. van Vliet, Ravian L. van Ineveld, Effrosyni Karaiskaki, Oded Kopper, Yotam E. Bar-Ephraim, Kai Kretzschmar, Alexander M.M. Eggermont, Ellen J. Wehrens, Henk G. Stunnenberg, Hans Clevers, Jürgen Kuball, Zsolt Sebestyen, Anne C. Rios
PDF Cite
Behavioral-transcriptomic landscape of engineered T cells targeting human cancer organoids
Reprogramming of pro-tumor macrophages by hydroxychloroquine in an abdominally metastasized diffuse midline glioma
Macrophage (Mφ) repolarization from a pro-tumor, immunosuppressive phenotype towards an anti-tumor, pro-inflammatory state represents a …
Hendrik G Stunnenberg, Cristian Ruiz-Moreno, Farid Keramati, Peter Brazda, Wout Megchelenbrink, Brigit te Pas, Kim Boshuisen, Helena C Besse, Lennart Kester, Mariette Kranendonk
PDF Cite
Reprogramming of pro-tumor macrophages by hydroxychloroquine in an abdominally metastasized diffuse midline glioma
Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties
RATIONALE: Mycobacterium vaccae (NCTC 11659) is an environmental saprophytic bacterium with anti-inflammatory, immunoregulatory, and …
Roberta Martinelli, Gurdyal S. Besra, Petr A. Illarionov, Istvan Szatmari, Peter Brazda, Mary A. Allen, Wenqing Xu, Xiang Wang, László Nagy, Robin D. Dowell, Graham A. W. Rook, Laura Rosa Brunet, Christopher A. Lowry David G. Smith
PDF Cite
Simultaneous mapping of molecular proximity and comobility reveals agonist-enhanced dimerization and DNA binding of nuclear receptors
Single Plane Illumination Microscopy (SPIM) revolutionized time lapse imaging of live cells and organisms due to its high speed and …
Bálint Rehó, Lukas Lau, Gábor Mocsár, Gabriele Müller, Lina Fadel, Peter Brazda, Laszlo Nagy, Katalin Toth, Gyorgy Vamosi
PDF Cite
Simultaneous mapping of molecular proximity and comobility reveals agonist-enhanced dimerization and DNA binding of nuclear receptors
Single cell transcriptome atlas of immune cells in human small intestine and in celiac disease
Celiac disease (CeD) is an autoimmune disorder in which ingestion of dietary gluten triggers an immune reaction in the small intestine. …
Nader Atlasy, Anna Bujko, Peter Brazda, Eva Janssen-Megens, Espen S Bækkevold, Jørgen Jahnsen, Frode L Jahnsen, Hendrik G Stunnenberg
PDF Cite
Single cell transcriptome atlas of immune cells in human small intestine and in celiac disease
Determination of dynamic properties of nuclear receptors
We characterized and compared the nuclear dynamics of RXR and RAR during activation in single cells on the sub-second scale using …
Peter Brazda
PDF Cite
Ligand binding shifts highly mobile retinoid X receptor to the chromatin-bound state in a coactivator-dependent manner, as revealed by single-cell imaging
Retinoid X receptor (RXR) is a promiscuous nuclear receptor forming heterodimers with several other receptors, which activate different …
Peter Brazda, Jan Krieger, Bence Daniel, David Jonas, Tibor Szekeres, Jörg Langowski, Katalin Toth, Laszlo Nagy, Gyorgy Vamosi
PDF Cite
Ligand binding shifts highly mobile retinoid X receptor to the chromatin-bound state in a coactivator-dependent manner, as revealed by single-cell imaging
Protein Interaction and Transport Maps of Live Cell Nuclei Using Fluorescence Correlation Spectroscopy in a Single Plane Illumination Microscope
Proteins acting on DNA need to penetrate a dense network of chromatin and associated macromolecules in the cell nucleus to access their …
Jan W Krieger, Agata Pernus, Peter Brazda, Jörg Langowski
PDF Cite