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Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells
Few cancers can be targeted efficiently by engineered T cell strategies. Here, we show that γδ T cell antigen receptor (γδ …
Patricia Hernández-López, Eline van Diest, Peter Brazda, Sabine Heijhuurs, Angelo Meringa, Lauren Hoorens van Heyningen, Caterina Riillo, Caroline Schwenzel, Marina Zintchenko, Inez Johann, Mara J. T. Nicolasen, Astrid Cleven, Thomas A. Kluiver, Rosemary Millen, Jiali Zheng, Froso Karaiskaki, Trudy Straetemans, Hans Clevers, Remco de Bree, Hendrik G. Stunnenberg, Weng Chuan Peng, Jeanine Roodhart, Susana Minguet, Zsolt Sebestyen, Dennis X. Beringer, Jürgen Kuball
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Agonist-controlled competition of RAR and VDR nuclear receptors for heterodimerization with RXR is manifested in their DNA-binding
We found previously that nuclear receptors (NRs) compete for heterodimerization with their common partner, retinoid X receptor (RXR), …
Bálint Rehó, Lina Fadel, Peter Brazda, Anass Benziane, Éva Hegedüs, Pialy Sen, Theodorus W.J. Gadella, Katalin Toth, Laszlo Nagy, Gyorgy Vamosi
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Agonist-controlled competition of RAR and VDR nuclear receptors for heterodimerization with RXR is manifested in their DNA-binding
Single cell transcriptomic analysis of the immune cell compartment in the human small intestine and in Celiac disease
Celiac disease is an autoimmune disorder in which ingestion of dietary gluten triggers an immune reaction in the small intestine …
Nader Atlasy, Anna Bujko, Espen S Bækkevold, Peter Brazda, Eva Janssen-Megens, Knut E A Lundin, Jørgen Jahnsen, Frode L Jahnsen, Hendrik G Stunnenberg
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Single cell transcriptomic analysis of the immune cell compartment in the human small intestine and in Celiac disease
Extensive patient-to-patient single nuclei transcriptome heterogeneity in pheochromocytomas and paragangliomas
Pheochromocytomas (PC) and paragangliomas (PG) are rare neuroendocrine tumors with varied genetic makeup and are associated with high …
Peter Brazda, Cristian Ruiz-Moreno, Wout Megchelenbrink, Henri J L M Timmers, Hendrik G Stunnenberg
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Extensive patient-to-patient single nuclei transcriptome heterogeneity in pheochromocytomas and paragangliomas
Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia
Background Acute myeloid leukemia (AML) is a heterogeneous and aggressive blood cancer that results from diverse genetic aberrations in …
Yanan Zhai, Prashant Singh, Anna Dolnik, Peter Brazda, Nader Atlasy, Nunzio del Gaudio, Konstanze Döhner, Hartmut Döhner, Saverio Minucci, Joost Martens, Lucia Altucci, Wout Megchelenbrink, Lars Bullinger, Hendrik G. Stunnenberg
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Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia
Uncovering the mode of action of engineered T cells in patient cancer organoids
Extending the success of cellular immunotherapies against blood cancers to the realm of solid tumors will require improved in vitro …
Johanna F Dekkers, Maria Alieva, Astrid Cleven, Farid Keramati, Peter Brazda, Heggert G Rebel, Amber KL Wezenaar, Jens Puschhof, Maj-Britt Buchholz, Mario Barrera Román, Inez Johanna, Angelo D. Meringa, Domenico Fasci, Maarten H. Geurts, Hendrikus C.R. Ariese, Esmée J. van Vliet, Ravian L. van Ineveld, Effrosyni Karaiskaki, Oded Kopper, Yotam E. Bar-Ephraim, Kai Kretzschmar, Alexander M.M. Eggermont, Ellen J. Wehrens, Henk G. Stunnenberg, Hans Clevers, Jürgen Kuball, Zsolt Sebestyen, Anne C. Rios
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Uncovering the mode of action of engineered T cells in patient cancer organoids
Reprogramming of pro-tumor macrophages by hydroxychloroquine in an abdominally metastasized diffuse midline glioma
Macrophage (Mφ) repolarization from a pro-tumor, immunosuppressive phenotype towards an anti-tumor, pro-inflammatory state represents a …
Hendrik G Stunnenberg, Cristian Ruiz-Moreno, Farid Keramati, Peter Brazda, Wout Megchelenbrink, Brigit te Pas, Kim Boshuisen, Helena C Besse, Lennart Kester, Mariette Kranendonk
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Reprogramming of pro-tumor macrophages by hydroxychloroquine in an abdominally metastasized diffuse midline glioma
Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties
RATIONALE: Mycobacterium vaccae (NCTC 11659) is an environmental saprophytic bacterium with anti-inflammatory, immunoregulatory, and …
Roberta Martinelli, Gurdyal S. Besra, Petr A. Illarionov, Istvan Szatmari, Peter Brazda, Mary A. Allen, Wenqing Xu, Xiang Wang, László Nagy, Robin D. Dowell, Graham A. W. Rook, Laura Rosa Brunet, Christopher A. Lowry David G. Smith
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Simultaneous mapping of molecular proximity and comobility reveals agonist-enhanced dimerization and DNA binding of nuclear receptors
Single Plane Illumination Microscopy (SPIM) revolutionized time lapse imaging of live cells and organisms due to its high speed and …
Bálint Rehó, Lukas Lau, Gábor Mocsár, Gabriele Müller, Lina Fadel, Peter Brazda, Laszlo Nagy, Katalin Toth, Gyorgy Vamosi
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Simultaneous mapping of molecular proximity and comobility reveals agonist-enhanced dimerization and DNA binding of nuclear receptors
Determination of dynamic properties of nuclear receptors
We characterized and compared the nuclear dynamics of RXR and RAR during activation in single cells on the sub-second scale using …
Peter Brazda
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