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Mapping T cell dynamics to molecular profiles through behavior-guided transcriptomics
This study introduces Behavior-Guided Transcriptomics (BGT), an extension to the BEHAV3D protocol, integrating T cell live imaging data …
A. K. L. Wezenaar, U. Pandey, F. Keramati, M. Hernandez-Roca, Peter Brazda, M. Barrera Román, A. Cleven, F. Karaiskaki, T. Aarts-Riemens, S. de Blank, P. Hernandez-Lopez, S. Heijhuurs, A. Alemany, J. Kuball, Z. Sebestyen, J. F. Dekkers, H. G. Stunnenberg, M. Alieva, A. C. Rios
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Mapping T cell dynamics to molecular profiles through behavior-guided transcriptomics
A longitudinal single-cell atlas to predict outcome and toxicity after BCMA-directed CAR T cell therapy in multiple myeloma
This study presents a longitudinal single-cell multi-omics atlas of immune dynamics in multiple myeloma patients treated with …
Michael Rade, David Fandrei, Markus Kreuz, Sabine Seiffert, Thomas Wiemers, Patrick Born, Luise Fischer, Heike Weidner, Lorenz Hofbauer, Ronny Baber, Song-Yau Wang, Enrica Bach, Sandra Hoffmann, Jonathan Scolnick, Mirco Friedrich, Farid Keramati, Peter Brazda, Zsolt Sebestyen, Jürgen Kuball, Klaus Metzeler, Marco Herling, Carmen Herling, Madlen Jentzsch, Georg-Nikolaus Franke, Andreas Boldt, Anja Grahnert, Maik Friedrich, Ulrike Köhl, Uwe Platzbecker, Vladan Vucinic, Kristin Reiche, Maximilian Merz
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A longitudinal single-cell atlas to predict outcome and toxicity after BCMA-directed CAR T cell therapy in multiple myeloma
Sensitivity to Vg9Vδ2TCR T cells is imprinted after single mutations during early oncogenesis
Vγ9Vδ2T cells have the unique ability to recognize a broad range of malignant transformed cells. The tumor targeting event involving …
Peter Brazda, Astrid Cleven *, Angelo D. Meringa *, Domenico Fasci, Thijs Koorman, Tineke Aarts, Inez Johanna, Dennis X Beringer, Patricia Hernandez-Lopez, Sabine Heijhuurs, Tomohiro Mizutani, Sangho Lim, Maarten Huismans, Jochem Bernink, David Vargas Diaz, Wei Wu, Esther San Jose, Jelle Schipper, Nikos Tsakirakis, Lauren Hoorens van Heyningen, Annick Nouwens, Lucrezia Gatti, Trudy Straetemans, Hugo Snippert, Jeanine Roodhart, Patrick W.B. Derksen, Jarno Drost, Maarten Altelaar, Albert J.R. Heck, Hans Clevers, Juergen Kuball, Zsolt Sebestyen
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Sensitivity to Vg9Vδ2TCR T cells is imprinted after single mutations during early oncogenesis
Antiviral responses induced by Tdap-IPV vaccination are associated with persistent humoral immunity to Bordetella pertussis
Many countries continue to experience pertussis epidemics despite widespread vaccination. Waning protection after booster vaccination …
Joshua Gillard, Madeleine Suffiotti, Peter Brazda, Prashanna B. Venkatasubramanian, Pauline Versteegen, Marien I. de Jonge, Dominic Kelly, Sagida Bibi, Marta Valente Pinto, Elles Simonetti, Mihaela Babiceanu, Andrew Kettring, Cristina Teodosio, Ronald de Groot, Guy Berbers, Hendrik G. Stunnenberg, Brian Schanen, Craig Fenwick, Martijn A. Huynen, Dimitri A. Diavatopoulos
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Antiviral responses induced by Tdap-IPV vaccination are associated with persistent humoral immunity to Bordetella pertussis
Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells
Few cancers can be targeted efficiently by engineered T cell strategies. Here, we show that γδ T cell antigen receptor (γδ …
Patricia Hernandez-Lopez, Eline van Diest, Peter Brazda, Sabine Heijhuurs, Angelo Meringa, Lauren Hoorens van Heyningen, Caterina Riillo, Caroline Schwenzel, Marina Zintchenko, Inez Johann, Mara J. T. Nicolasen, Astrid Cleven *, Thomas A. Kluiver, Rosemary Millen, Jiali Zheng, Froso Karaiskaki, Trudy Straetemans, Hans Clevers, Remco de Bree, Hendrik G. Stunnenberg, Weng Chuan Peng, Jeanine Roodhart, Susana Minguet, Zsolt Sebestyen, Dennis X. Beringer, Jürgen Kuball
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Agonist-controlled competition of RAR and VDR nuclear receptors for heterodimerization with RXR is manifested in their DNA-binding
We found previously that nuclear receptors (NRs) compete for heterodimerization with their common partner, retinoid X receptor (RXR), …
Bálint Rehó, Lina Fadel, Peter Brazda, Anass Benziane, Éva Hegedüs, Pialy Sen, Theodorus W.J. Gadella, Katalin Toth, Laszlo Nagy, Gyorgy Vamosi
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Agonist-controlled competition of RAR and VDR nuclear receptors for heterodimerization with RXR is manifested in their DNA-binding
Single cell transcriptomic analysis of the immune cell compartment in the human small intestine and in Celiac disease
Celiac disease is an autoimmune disorder in which ingestion of dietary gluten triggers an immune reaction in the small intestine …
Nader Atlasy, Anna Bujko, Espen S Bækkevold, Peter Brazda, Eva Janssen-Megens, Knut E A Lundin, Jørgen Jahnsen, Frode L Jahnsen, Hendrik G Stunnenberg
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Single cell transcriptomic analysis of the immune cell compartment in the human small intestine and in Celiac disease
Extensive patient-to-patient single nuclei transcriptome heterogeneity in pheochromocytomas and paragangliomas
Pheochromocytomas (PC) and paragangliomas (PG) are rare neuroendocrine tumors with varied genetic makeup and are associated with high …
Peter Brazda, Cristian Ruiz-Moreno, Wout Megchelenbrink, Henri J L M Timmers, Hendrik G Stunnenberg
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Extensive patient-to-patient single nuclei transcriptome heterogeneity in pheochromocytomas and paragangliomas
Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia
Background Acute myeloid leukemia (AML) is a heterogeneous and aggressive blood cancer that results from diverse genetic aberrations in …
Yanan Zhai, Prashant Singh, Anna Dolnik, Peter Brazda, Nader Atlasy, Nunzio del Gaudio, Konstanze Döhner, Hartmut Döhner, Saverio Minucci, Joost Martens, Lucia Altucci, Wout Megchelenbrink, Lars Bullinger, Hendrik G. Stunnenberg
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Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia
Uncovering the mode of action of engineered T cells in patient cancer organoids
Extending the success of cellular immunotherapies against blood cancers to the realm of solid tumors will require improved in vitro …
Johanna F Dekkers, Maria Alieva, Astrid Cleven *, Farid Keramati, Peter Brazda, Heggert G Rebel, Amber KL Wezenaar, Jens Puschhof, Maj-Britt Buchholz, Mario Barrera Román, Inez Johanna, Angelo D. Meringa *, Domenico Fasci, Maarten H. Geurts, Hendrikus C.R. Ariese, Esmée J. van Vliet, Ravian L. van Ineveld, Effrosyni Karaiskaki, Oded Kopper, Yotam E. Bar-Ephraim, Kai Kretzschmar, Alexander M.M. Eggermont, Ellen J. Wehrens, Henk G. Stunnenberg, Hans Clevers, Jürgen Kuball, Zsolt Sebestyen, Anne C. Rios
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Uncovering the mode of action of engineered T cells in patient cancer organoids